Development of a novel therapeutic approach for periodontitis that utilizes GMSCs-derived exosome through induction of M2 macrophage

Periodontitis is one of the most common osteolytic inflammatory diseases in humans. Formation a periodontal bacteria-associated biofilm thought to be trigger for development periodontitis, but it not believed sufficient by itself sustain disease, as compromise host immune response critical tissue breakdown and disease progression. Macrophages play an important role both during initiation resolution inflammation. are broadly classified into two phenotypes, pro-inflammatory M1 wound-healing M2 cells. Since macrophages contribute tissue-remodeling process, effective macrophage induction would provide favorable environment inflammation regeneration.